tibco spotfire 6.0.0 (TIBCO)
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tibco spotfire 6.0.0
Tibco Spotfire 6.0.0, supplied by TIBCO, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/tibco+spotfire+6%2E0%2E0/tibco+spotfire+6+0+0/pmc10983791-459-10-13
Average 90 stars, based on 1 article reviews
Tibco Spotfire 6.0.0, supplied by TIBCO, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/tibco+spotfire+6%2E0%2E0/tibco+spotfire+6+0+0/pmc10983791-459-10-13
Average 90 stars, based on 1 article reviews
tibco spotfire 6.0.0 - by Bioz Stars,
2026-11
90/100 stars
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1) Product Images from "Target class profiling of small molecule methyltransferases"
Article Title: Target class profiling of small molecule methyltransferases
Journal: ACS chemical biology
doi: 10.1021/acschembio.3c00124
Figure Legend Snippet: A) Cluster analysis of Diversity Library hits. Compounds were clustered according to chemical similarity (based on Tanimoto coefficient) and a heat map was generated to show relative activity. Chemical clusters with high activity, such as the HNMT selective cluster (blue) reveal selective chemotypes for a single SMMTase. Bands of high activity indicate pan inhibitors of the representative SMMTases (green). B) Chemotype of top HNMT-selective hit enables cheminformatic R-group decompositions. R group decomposition was performed using TIBCO Spotfire (TIBCO Software Inc.). Compound activity (displayed as area under the curve, AUC) was plotted as a function of R2 functional group identity. R1 group identity is color coded blue for hydrogen and orange for methoxy. C) The R2 group in NCGC00411246 yields a highly active and specific compounds. R groups which result in reduced specificity (e.g., NCGC00411220) or reduce activity (e.g., NCGC00411154) we also observed.
Techniques Used: Generated, Activity Assay, Software, Functional Assay
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Article Snippet: Quantitative image analysis was conducted using Article Title: Target class profiling of small molecule methyltransferases Article Snippet: Clustering of compounds by activity outcomes Compounds were clustered hierarchically using Article Title: Target class profiling of small molecule methyltransferases Article Snippet: All data were analyzed and processed using in-house tools and Article Title: Target Class Profiling of Small-Molecule Methyltransferases. Article Snippet: All data were analyzed and processed using in-house tools and Software:Article Title: Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing Article Snippet: Compounds were clustered hierarchically within Article Title: Target class profiling of small molecule methyltransferases Article Snippet: Compounds were clustered hierarchically using Article Title: Target Class Profiling of Small-Molecule Methyltransferases. 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